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Home Antibody All anti-NR4A1 antibodies

Anti-NR4A1 Antibody EPR3209

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307475
  • Rabbit monoclonal antibody against Nur77(clone EPR3209)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC429089) , 20ug
100ul 325 In Stock
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WB(1)
FC(1)
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Also for NR4A1 (NM_002135)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human Nur77 was used as an immunogen.
Clone NameEPR3209 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens nuclear receptor subfamily 4, group A, member 1 (NR4A1), transcript variant 1
Alternative NameGFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77; TR3
Database LinkNP_002126
FunctionNur77 (TR3, NGFI-B) is an orphan nuclear receptor belonging to the steroid/thyroid hormone receptor superfamily with multiple cell functions relating to apoptosis, cell differentiation, and proliferation. Nur77 expression is rapidly induced by several growth factors, mitogens, and stress factors (1). With its central DNA binding domain, Nur77 binds to specific DNA elements and regulates the transcription of the target gene (2). While Nur77 activities are shown to be specific to its sub-cellular location, the phospholyation on Nur77 by various kinases (e.g. RSK, MSK) might affect its transactivation activity and its localization (3, 4). Nur77 localized in the nucleus functions as an oncogenic survival factor and promotes cell growth. However, in mitochondria, it functions as an apoptosis factor after binding to Bcl-2 and triggering cytochrome c release. Nur77 has been linked to apoptosis of immature T cell and T cell hybridoma. In tumors, it is involved in both apoptosis and proliferation of cancer cells (4).
Related Pathway
MAPK signaling pathway

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WB Image
Western blot - NUR77 antibody [EPR3209]; All lanes : Anti-NUR77 antibody [EPR3209] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate.Lane 2 : HepG2 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 64 kDa.Observed band size : 64 kDa.
FC Image
Flow Cytometry - NUR77 antibody [EPR3209]; Flow cytometric analysis of permeabilized HepG2 cells using TA307475 at 1/10 (red) or a rabbit IgG in (green negative control).

 

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