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Anti-TNC Antibody EPR4219


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307471 Rabbit monoclonal antibody against Tenascin-C(clone EPR4219) 100ul $325 3-7 Days
LC419496 TNC HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Tenascin-C was used as an immunogen.
Clone NameEPR4219 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:1000; IHC-Fr: Use at an assay dependent concentration
Predicted MW Explanation 241 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens tenascin C (TNC)
Alternative Name150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C
Database LinkNP_002151
Entrez Gene 3371 Human
Entrez Gene 21923 Mouse
Entrez Gene 116640 Rat
FunctionTenascin-C is the founding member of a family of extracellular matrix glycoproteins that includes tenascin-X, -R and -W. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses (1). It also modulates cell migration; proliferation; and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules, amongst other mechanisms (1). Tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer (1). In the adult, Tenascin-C remains present in tendons and myotendinous junctions in the perichondrium and periosteum, as well as in smooth muscle (2).
Related PathwaySecreted ProteinES Cell Differentiation/IPSTransmembraneDruggable Genome Focal adhesionECM-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


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