Tenascin-C is the founding member of a family of extracellular matrix glycoproteins that includes tenascin-X, -R and -W. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses (1). It also modulates cell migration; proliferation; and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules, amongst other mechanisms (1). Tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer (1). In the adult, Tenascin-C remains present in tendons and myotendinous junctions in the perichondrium and periosteum, as well as in smooth muscle (2).
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