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Home Antibody All anti-IDO1 antibodies

Anti-IDO1 Antibody EPR1230Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307468
  • Rabbit monoclonal antibody against IDO(clone EPR1230Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400784) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for IDO1 (NM_002164)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen A synthetic peptide corresponding to residues within human IDO was used as an immunogen.
Clone NameEPR1230Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:2500 - 1:5000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens indoleamine 2,3-dioxygenase 1 (IDO1)
Alternative NameIDO; IDO-1; INDO
Database LinkNP_002155
FunctionT lymphocytes undergo proliferation arrest when exposed to tryptophan shortage, which can be provoked by indoleamine 2,3-dioxygenase (IDO), an enzyme that is expressed in placenta and catalyzes tryptophan degradation. Here we show that most human tumors constitutively express IDO. Results suggest that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor (1). Certain macrophages, induced to express IDO in response to interferon-gamma and other signals from activating T cells, inhibit T-cell proliferation in vitro by rapidly consuming tryptophan. Because IDO is also expressed by human syncytiotrophoblast cells and systemic tryptophan concentration falls during normal pregnancy, it is believed that IDO expression at the maternal-fetal interface is necessary to prevent immunologic rejection of the fetal allografts (2).
Related Pathway

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WB Image
Western blot - Indoleamine 2, 3-dioxygenase antibody [EPR1230Y]; Anti-Indoleamine 2, 3-dioxygenase antibody [EPR1230Y] at 1/5000 dilution + HeLa cell lysate treated with IFN gamma at 10 µg.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 45 kDa.Observed band size : 45 kDa.

 

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