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Anti-IDO1 Antibody EPR1230Y
Also for IDO1 (NM_002164)
| A synthetic peptide corresponding to residues within human IDO was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:2500 - 1:5000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1)|
|IDO; IDO-1; INDO|
Entrez Gene 3620 Human
|T lymphocytes undergo proliferation arrest when exposed to tryptophan shortage, which can be provoked by indoleamine 2,3-dioxygenase (IDO), an enzyme that is expressed in placenta and catalyzes tryptophan degradation. Here we show that most human tumors constitutively express IDO. Results suggest that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor (1). Certain macrophages, induced to express IDO in response to interferon-gamma and other signals from activating T cells, inhibit T-cell proliferation in vitro by rapidly consuming tryptophan. Because IDO is also expressed by human syncytiotrophoblast cells and systemic tryptophan concentration falls during normal pregnancy, it is believed that IDO expression at the maternal-fetal interface is necessary to prevent immunologic rejection of the fetal allografts (2).|
|Druggable Genome Tryptophan metabolismMetabolic pathways|
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Western blot - Indoleamine 2, 3-dioxygenase antibody [EPR1230Y]; Anti-Indoleamine 2, 3-dioxygenase antibody [EPR1230Y] at 1/5000 dilution + HeLa cell lysate treated with IFN gamma at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 45 kDa.Observed band size : 45 kDa.