The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch family are transmembrane receptors that are critical for various cell fate decisions. Jagged2 is one of several ligands that activate Notch and related receptors (1). It is also expressed in the heart, placenta and skeletal muscle and to a lesser extend in pancreas (2).
Delta-Notch Signaling Pathway
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