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Anti-KRT4 Antibody EPR1598
Also for KRT4 (NM_002272)
|A synthetic peptide corresponding to residues in human Cytokeratin 4 was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||ICC: 1: 100 - 250, IHC: 1: 100 - 250, WB: 1: 1,000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse
|Homo sapiens keratin 4 (KRT4)|
|CK-4; CK4; CYK4; K4; WSN1|
|Keratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells (1). Keratins are expressed in pairs by epithelial cells in a tissue and cell specific manner (2). The major differentiation specific keratins of the buccal mucosa, nasal, esophageal and anogenital epithelia are cytokeratin 4 and cytokeratn 13 (2). Cytokeratin 4 and cytokeratin 13 form heterodimers in normal epithelial cells (3). In humans, cytokeratin 4 is present in all layers of the epidermis at 10 weeks and gradually disappears (3). Genetic mutations in cytokeratin 4 cause white sponge nevus (WSN), an autosomal dominant disorder that affects noncornified stratified squamous epithelia (4).|
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Western blot - Cytokeratin 4 antibody [EPR1598]; All lanes : Anti-Cytokeratin 4 antibody [EPR1598] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Human uterus cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 57 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 4 antibody [EPR1598]; TA307460, at a 1/100 dilution, staining Cytokeratin 4 in paraffin embedded Human tonsil tissue by Immunohistochemistry. Note positive staining of squamous cells.
Immunocytochemistry/ Immunofluorescence - Cytokeratin 4 antibody [EPR1598]; Immunofluorescent staining of A431 cells, using TA307460 at a 1/100 dilution.