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Home Antibody All anti-KRT4 antibodies

Anti-KRT4 Antibody EPR1598

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307460
  • Rabbit monoclonal antibody against Cytokeratin 4(clone EPR1598)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419424) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Cytokeratin 4 was used as an immunogen.
Clone NameEPR1598 IsotypeIgG
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC: 1: 100 - 250, IHC: 1: 100 - 250, WB: 1: 1,000 - 10,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse

Reference Data

Target NameHomo sapiens keratin 4 (KRT4)
Alternative NameCK-4; CK4; CYK4; K4; WSN1
Database LinkNP_002263
FunctionKeratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells (1). Keratins are expressed in pairs by epithelial cells in a tissue and cell specific manner (2). The major differentiation specific keratins of the buccal mucosa, nasal, esophageal and anogenital epithelia are cytokeratin 4 and cytokeratn 13 (2). Cytokeratin 4 and cytokeratin 13 form heterodimers in normal epithelial cells (3). In humans, cytokeratin 4 is present in all layers of the epidermis at 10 weeks and gradually disappears (3). Genetic mutations in cytokeratin 4 cause white sponge nevus (WSN), an autosomal dominant disorder that affects noncornified stratified squamous epithelia (4).
Related Pathway

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WB Image
Western blot - Cytokeratin 4 antibody [EPR1598]; All lanes : Anti-Cytokeratin 4 antibody [EPR1598] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Human uterus cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 57 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 4 antibody [EPR1598]; TA307460, at a 1/100 dilution, staining Cytokeratin 4 in paraffin embedded Human tonsil tissue by Immunohistochemistry. Note positive staining of squamous cells.
IF Image
Immunocytochemistry/ Immunofluorescence - Cytokeratin 4 antibody [EPR1598]; Immunofluorescent staining of A431 cells, using TA307460 at a 1/100 dilution.

 

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