The LDL receptor-related protein (LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse roles in various biological processes including lipoprotein metabolism, degradation of proteases, activation of lysosomal enzymes, and cellular entry of bacterial toxins and viruses. LRP1 can recognize more than 30 distinct ligands, bind a large number of cytoplasmic adaptor proteins via determinants located on its cytoplasmic domain in a phosphorylation-specific manner, and can associate with and modulate the activity of other transmembrane receptors such as integrins and receptor tyrosine kinases (1). This multi-talented receptor has been implicated in regulation of platelet derived growth factor receptor activity, integrin maturation and recycling, and focal adhesion disassembly (2).
Wnt Signaling Pathway
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Western blot analysis on (A) PMBC, (B) A549, (C) mouse brain, (D) mouse heart, (E) mouse kidney, (F) mouse spleen, (G) rat brain, (H) rat heart, (I) rat kidney and (J) rat spleen lysates using anti-LRP1 RabMAb .