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Anti-MMP8 Antibody EP1252Y
Also for MMP8 (NM_002424)
|A synthetic peptide corresponding to residues in human MMP-8 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000; ICC: 1:100 - 1:250; IHC-P: 1:100 - 1:250; FC: 1:20; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens matrix metallopeptidase 8 (MMP8), transcript variant 1|
|CLG1; HNC; MMP-8; PMNL-CL|
Entrez Gene 4317 Human
Entrez Gene 17394 Mouse
Entrez Gene 63849 Rat
|The matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumor invasion and tumour spread (1). Matrix Metalloporteinase 8 (MMP-8, Collagenase-2, Neutrophil Collagenase) functions mainly to degrade fibrillar type I, II, and III collagens, serpins, and aggrecan. MMP-8 degrades by cleaving at one specific on the fibrillar collagens with higher cleave activity on type I compared to type III collagens. MMP-8 is expressed in neutrophils, chondrocytes, and gingival fibroblasts (2). |
|ProteaseDruggable Genome |
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Western blot - MMP8 antibody [EP1252Y]; Anti-MMP8 antibody [EP1252Y] at 1/2000 dilution + Rat lung lysate at 10 ug.Secondary.HRP conjugated goat anti-rabbit at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 72 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MMP8 antibody [EP1252Y]; TA307445, at 1/100 dilution, staining MMP8 in human placenta by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MMP8 antibody [EP1252Y]; TA307445, at 1/100 dilution, staining MMP8 in human urinary bladder carcinoma by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.