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Anti-PAWR Antibody EPR3992


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against PAR4(clone EPR3992)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419234) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human PAR4 was used as an immunogen.
Clone NameEPR3992 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 37 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens PRKC, apoptosis, WT1, regulator (PAWR)
Alternative NamePar-4; PAR4
Database LinkNP_002574
Entrez Gene 5074 Human
Entrez Gene 114774 Mouse
Entrez Gene 64513 Rat
FunctionProstate apoptosis response protein (PAR4) is a proapoptotic protein with intracellular functions in the cytoplasm and nucleus, capable of suppressing tumors (1). Extracellular PAR4 induces apoptosis by binding to the stress response protein, glucose-regulated protein-78 (GRP78), via an extrinsic pathway (1). PAR4 contains leucine zipper and death domains that are upregulated in prostate cancer cells and hippocampal neurons induced to undergo apoptosis (2). Alzheimer's and Parkinson's diseases are both targets for PAR-4 in treatments that block its expression, preventing neuronal cell death (3). In Parkinson's disease, the death of dopaminergic neurons follows a degenerative pathway that circumvents the apoptotic induction of PAR-4 (4). An isoform of PAR-4, PAR-4/p33, prevents apoptosis in neural stem cells and does not activate caspase 3 (5).
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - PAR4 antibody [EPR3992]; All lanes : Anti-PAR4 antibody [EPR3992] at 1/1000 dilution.Lane 1 : LnCaP cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : A549 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 37 kDa.Observed band size : 43 kDa .


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