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Anti-PDZK1 Antibody EPR3751
Also for PDZK1 (NM_002614)
|A synthetic peptide corresponding to residues in human PDZK1 was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||FC: 1:50, ICC: 1:100 - 250, IHC: 1:100 - 250, IP: 1:50, WB: 1:5,000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens PDZ domain containing 1 (PDZK1), transcript variant 1|
|CAP70; CLAMP; NHERF-3; NHERF3; PDZD1|
|PDZ domain-containing protein 1 (PDZK1) is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells (1). PDZK1 is suggested to play multiple roles in normal physiology and may influence associated disorders. It is involved in maintaining hepatic SR-BI levels and controlling HDL metabolism, protects against the development of atherosclerosis and also mediates SR-BI-dependent regulation of endothelial cell biology by HDL (2). PDZK1 expression is limited to epithelial cells, located in the kidney, pancreas, liver, and small intestine. It is also expressed at a lower level in the adrenal cortex, testis and stomach, and it is over-expressed in breast, renal and lung carcinomas (1). |
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Western blot - PDZK1 antibody [EPR3751]; All lanes : Anti-PDZK1 antibody [EPR3751] at 1/5000 dilution.Lane 1 : Human fetal liver lysate.Lane 2 : Human fetal kidney lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 57 kDa.Observed band size : 70 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PDZK1 antibody [EPR3751]; TA307425 at 1/100 dilution staining PDZK1 in Human kidney tissue by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
Immunocytochemistry/ Immunofluorescence - PDZK1 antibody [EPR3751]; TA307425 at 1/100 staining PDZK1 in HeLa cells by Immunofluorescence.