Phospholamban is a major substrate for the cAMP-dependent kinase in cardiac muscle. It regulates the activity of the calcium pump of cardiac sarcoplasmic reticulum. It inhibits cardiac muscle sarcoplasmic reticulum Ca2+-ATPase in the unphosphoyrlated state, but inhibition is relieved upon phosphorylation of the protein (1). Beta-adrenergic stimulation results in PLB phosphorylation by both cAMP-dependent protein kinase at Serine 16 and calcium/calmodulin-dependent protein kinase at Serine 17 (2). Phospholamban is expressed in slow twitch skeletal muscle and some smooth muscle as well as in cardiac muscle (1).
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