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Home Antibody All anti-PLN antibodies

Anti-PLN PHOSPHO Antibody EPR1911


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SKU Description Amount Price Availability*  
TA307421 Rabbit monoclonal antibody against Phospholamban Phospho (pS16) (clone EPR1911 ) (Phospho-Specific) 100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 16 of human Phospholamban was used as an immunogen.
Clone NameEPR1911 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsIP: 1:50, WB: 1:200,000 - 500,000,
Predicted MW Explanation 6 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Rat

Reference Data

Target NameHomo sapiens phospholamban (PLN)
Alternative NameCMD1P; CMH18; PLB
Database LinkNP_002658
Entrez Gene 5350 Human
Entrez Gene 18821 Mouse
FunctionPhospholamban is a major substrate for the cAMP-dependent kinase in cardiac muscle. It regulates the activity of the calcium pump of cardiac sarcoplasmic reticulum. It inhibits cardiac muscle sarcoplasmic reticulum Ca2+-ATPase in the unphosphoyrlated state, but inhibition is relieved upon phosphorylation of the protein (1). Beta-adrenergic stimulation results in PLB phosphorylation by both cAMP-dependent protein kinase at Serine 16 and calcium/calmodulin-dependent protein kinase at Serine 17 (2). Phospholamban is expressed in slow twitch skeletal muscle and some smooth muscle as well as in cardiac muscle (1).
Related PathwayTransmembrane Calcium signaling pathwayDilated cardiomyopathy

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