Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
A synthetic peptide corresponding to residues on the C-terminus in human PKC gamma was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types. PKC gamma is activated by various secondary messengers such as calcium, diacylglycerol, phosphatidylserine, and phorbol ester. After activation by phorbol, it moves to the cytoplasm and regulates intracellular communication in epithelial cells. PKC gamma expression is specific to neurons in the brain and spinal cord, playing an important role in neurogenerative signal transduction (1). It is required for neuronal processes such as long term potentiation (LTP) and long term depression (LTD). PKC has three phosphorylation sites in its kinase domain, which are critical for full activation of PKC in response to various stimulants (2). Mutations in the PKC gamma gene have been linked to the neurodegenerative disorder spinocerebellar ataxia-14 (SCA14) (3).
Related Pathway
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Focal Adhesion
Hemostasis
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Melanogenesis
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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