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Home Antibody All anti-PRKCG antibodies

Anti-PRKCG Antibody EPR2750

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307414
  • Rabbit monoclonal antibody against PKC Gamma(clone EPR2750)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419134) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for PRKCG (NM_002739)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus in human PKC gamma was used as an immunogen.
Clone NameEPR2750 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens protein kinase C, gamma (PRKCG)
Alternative NamePKC-gamma; PKCC; PKCG; SCA14
Database LinkNP_002730
Entrez Gene 5582 Human
Entrez Gene 18752 Mouse
Entrez Gene 24681 Rat
FunctionMembers of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types. PKC gamma is activated by various secondary messengers such as calcium, diacylglycerol, phosphatidylserine, and phorbol ester. After activation by phorbol, it moves to the cytoplasm and regulates intracellular communication in epithelial cells. PKC gamma expression is specific to neurons in the brain and spinal cord, playing an important role in neurogenerative signal transduction (1). It is required for neuronal processes such as long term potentiation (LTP) and long term depression (LTD). PKC has three phosphorylation sites in its kinase domain, which are critical for full activation of PKC in response to various stimulants (2). Mutations in the PKC gamma gene have been linked to the neurodegenerative disorder spinocerebellar ataxia-14 (SCA14) (3).
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
Hemostasis
MAPK signaling pathway
Melanogenesis
TGF Beta Signaling Pathway
Wnt Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PKC gamma antibody [EPR2750]; All lanes : Anti-PKC gamma antibody [EPR2750] at 1/1000 dilution.Lane 1 : Human fetal brain cell lysate.Lane 2 : Human fetal cerebellum cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 78 kDa.

 

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