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Home Antibody All anti-PKN1 antibodies

Anti-PKN1 Antibody EPR3237

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307412
  • Rabbit monoclonal antibody against PKN1(clone EPR3237)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419135) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for PKN1 (NM_002741)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human PKN1 was used as an immunogen.
Clone NameEPR3237 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens protein kinase N1 (PKN1), transcript variant 2
Alternative NameDBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1
Database LinkNP_002732
Entrez Gene 5585 Human
Entrez Gene 320795 Mouse
Entrez Gene 29355 Rat
FunctionProtein kinase N (PKN) is a fatty acid- and Rho-activated serine/threonine protein kinase involved in the regulation of cell motility by association with cytoskeletal components such as neurofilament and alpha-actinin (1). Serine/threonine-protein kinase N1 (PKN1) belongs to the protein kinase C superfamily. It is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The phosphorylation of PKN1 by PDK1 may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis (2).
Related PathwayProtein KinaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PKN antibody [EPR3237]; All lanes : Anti-PKN antibody [EPR3237] at 1/1000 dilution.Lane 1 : Jurkat lysates.Lane 2 : Human spleen lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 104 kDa.Observed band size : 120 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PKN antibody [EPR3237]; Immunohistochemical analysis of PKN in paraffin embedded Human brain tissue, using TA307412 at a 1/100 dilution.

 

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