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 Home All anti-RPA2 antibodies

Anti-RPA2 Antibody EPR2876(2)

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SKU Description Amount Price Availability*  
TA307402
  • Rabbit monoclonal antibody against RPA32(clone EPR2876(2))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401031) , 20ug
 100ul $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
Add to Shopping Cart
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
IHC(1)
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Also for RPA2 (NM_002946)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RPA32 was used as an immunogen.
Clone NameEPR2876(2) IsotypeRabbit IgG
Species ReactivityHuman, Rat Concentration
Guaranteed Application *WB, IHC Suggested DilutionsIHC: 1:250 - 500, WB: 1:1,000-10,000,
BufferStore at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens replication protein A2, 32kDa (RPA2)
Alternative NameREPA2; RPA32
Database LinkNP_002937
FunctionReplication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein that plays essential roles in nucleic acid metabolism, including DNA replication, nucleotide excision repair, and homologous recombination. It is a complex of three polypeptides (RPA70, RPA32, and RPA14). RPA is a phosphorylation target for DNA-dependent protein kinase (DNA-PK) and likely the ataxia telangiectasia-mutated gene (ATM) protein kinase. The middle subunit, RPA32, is phosphorylated in a cell cycle-dependent manner which begins in parallel to the degradation of DNA to high molecular weight fragments, and slowly continues until late apoptosis. Hyperphosphorylation of RPA32 requires the activities of DNA-dependent protein kinase and a cyclin-dependent protein kinase (1-3). RPA32 has been reported to be a useful prognostic indicator in colon cancer patients, and it is an attractive therapeutic target for regulation by tumor suppressors or other proteins involved in the control of cell proliferation (4).
Related Pathway
Cell cycle

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis on (A) HeLa, (B) HUVEC, (C) HepG2, and (D) MCF-7 cell lysates using anti-RPA32 RabMAb .
IHC Image
Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-RPA32 RabMAb .

 

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