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Anti-RPA2 Antibody EPR2876(2)
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Also for RPA2 (NM_002946)
|A synthetic peptide corresponding to residues in human RPA32 was used as an immunogen.|
||IHC: 1:250 - 500, WB: 1:1,000-10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens replication protein A2, 32kDa (RPA2)|
|Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein that plays essential roles in nucleic acid metabolism, including DNA replication, nucleotide excision repair, and homologous recombination. It is a complex of three polypeptides (RPA70, RPA32, and RPA14). RPA is a phosphorylation target for DNA-dependent protein kinase (DNA-PK) and likely the ataxia telangiectasia-mutated gene (ATM) protein kinase. The middle subunit, RPA32, is phosphorylated in a cell cycle-dependent manner which begins in parallel to the degradation of DNA to high molecular weight fragments, and slowly continues until late apoptosis. Hyperphosphorylation of RPA32 requires the activities of DNA-dependent protein kinase and a cyclin-dependent protein kinase (1-3). RPA32 has been reported to be a useful prognostic indicator in colon cancer patients, and it is an attractive therapeutic target for regulation by tumor suppressors or other proteins involved in the control of cell proliferation (4).|
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Western blot analysis on (A) HeLa, (B) HUVEC, (C) HepG2, and (D) MCF-7 cell lysates using anti-RPA32 RabMAb .
Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-RPA32 RabMAb .