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Anti-RPA2 Antibody EPR2876(2)
Also for RPA2 (NM_002946)
|A synthetic peptide corresponding to residues in human RPA32 was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500
|Does not react with Mouse. Is unsuitable for Flow Cyt,ICC or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens replication protein A2, 32kDa (RPA2), transcript variant 1|
|REPA2; RP-A p32; RP-A p34; RPA32|
|Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein that plays essential roles in nucleic acid metabolism, including DNA replication, nucleotide excision repair, and homologous recombination. It is a complex of three polypeptides (RPA70, RPA32, and RPA14). RPA is a phosphorylation target for DNA-dependent protein kinase (DNA-PK) and likely the ataxia telangiectasia-mutated gene (ATM) protein kinase. The middle subunit, RPA32, is phosphorylated in a cell cycle-dependent manner which begins in parallel to the degradation of DNA to high molecular weight fragments, and slowly continues until late apoptosis. Hyperphosphorylation of RPA32 requires the activities of DNA-dependent protein kinase and a cyclin-dependent protein kinase (1-3). RPA32 has been reported to be a useful prognostic indicator in colon cancer patients, and it is an attractive therapeutic target for regulation by tumor suppressors or other proteins involved in the control of cell proliferation (4).|
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Western blot - RPA32/RPA2 antibody [EPR2876(2)]; All lanes : Anti-RPA32/RPA2 antibody [EPR2876(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HUVEC cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 29 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RPA32/RPA2 antibody [EPR2876(2)]; TA307402 at 1/250 dilution staining RPA32/RPA2 in Human colon by Immunohistochemistry, Paraffin-embedded tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RPA32/RPA2 antibody [EPR2876(2)]; TA307402 at 1/250 dilution staining RPA32/RPA2 in Human ovary carcinoma by Immunohistochemistry, Paraffin-embedded tissue.