A synthetic peptide corresponding to residues in human MRP14/S100-A9 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
S100-A9 (MRP14) is a member of the S100 family proteins containing two EF-hand calcium-binding motifs (1). S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation (2). S100-A9 forms a heterodimer, Calprotectin, with S100-A8 in a calcium-dependent manner. Calprotectin is a major calcuim- and zinc-binding protein in the cytosol of neutrophils, monocytes, and keratinocytes (3). S100-A9 may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis (2).
Related Pathway
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Western blot analysis on (A) breast cancer, (B) human tonsil, (C) human spleen and (D) peripheral blood lymphocytes lysates using anti-MRP14/S100-A9 RabMAb .
