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Anti-SATB1 Antibody EPR3951
Also for SATB1 (NM_002971)
|A synthetic peptide corresponding to residues in human SATB1 was used as an immunogen.|
||Tissue culture supernatant
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; IHC-Fr: Use at an assay dependent concentration
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt.
|Homo sapiens SATB homeobox 1 (SATB1), transcript variant 1|
|DNA-binding protein SATB1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's); SATB homeobox 1|
Entrez Gene 6304 Human
Entrez Gene 20230 Mouse
|Special AT-rich sequence-binding protein 1 (SATB1) is a global chromatin organizer and nuclear transcription factor that integrates higher-order chromatin architecture with gene regulation (1). SATB1 specifically binds to nuclear matrix/scaffold-associating DNAs (MARs/SARs), which is made of AT-rich DNA sequences with one strand consisting of ATC sequences. Studies have shown that in cooperation with promyelocytic leukemia protein (PML), SATB1 and PML function as a regulatory complex that controls transcription by restructuring the dynamic chromatin-loop architecture. SATB1 interacts with PML to organize the MHC class-I locus into distinct higher-order chromatin loops by anchoring MARs to the nuclear matrix at fixed distances (2). As a key player in the immune system, SATB1 has been linked to regulating gene expression during the differentiation and activation of T cells. In cancer, SATB1 has been shown to reprogram chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis (3).|
|Transcription FactorsDruggable Genome |
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Western blot - SATB1 antibody [EPR3951]; All lanes : Anti-SATB1 antibody [EPR3951] at 1/1000 dilution.Lane 1 : Jurkat cell lysates.Lane 2 : Fetal thymus lysates.Lane 3 : Mouse thymus lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 86 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SATB1 antibody [EPR3951]; TA307396, at 1/100 dilution staining SATB1 in paraffin-embedded Human breast carcinoma, by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SATB1 antibody [EPR3951]; TA307396, at 1/100 dilution staining SATB1 in paraffin-embedded Human ovarian adenocarcinoma tissue, by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SATB1 antibody [EPR3951]; TA307396, at 1/100 dilution staining SATB1 in paraffin-embedded Human tonsil tissue, by Immunohistochemistry.