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Home Antibody All anti-SATB1 antibodies

Anti-SATB1 Antibody EPR3951

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307396
  • Rabbit monoclonal antibody against SATB1(clone EPR3951)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418976) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(3)
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Also for SATB1 (NM_002971)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human SATB1 was used as an immunogen.
Clone NameEPR3951 IsotypeTissue culture supernatant
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; IHC-Fr: Use at an assay dependent concentration
BufferDoes not react with Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens SATB homeobox 1 (SATB1), transcript variant 1
Alternative NameDNA-binding protein SATB1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's); SATB homeobox 1
Database LinkNP_002962
FunctionSpecial AT-rich sequence-binding protein 1 (SATB1) is a global chromatin organizer and nuclear transcription factor that integrates higher-order chromatin architecture with gene regulation (1). SATB1 specifically binds to nuclear matrix/scaffold-associating DNAs (MARs/SARs), which is made of AT-rich DNA sequences with one strand consisting of ATC sequences. Studies have shown that in cooperation with promyelocytic leukemia protein (PML), SATB1 and PML function as a regulatory complex that controls transcription by restructuring the dynamic chromatin-loop architecture. SATB1 interacts with PML to organize the MHC class-I locus into distinct higher-order chromatin loops by anchoring MARs to the nuclear matrix at fixed distances (2). As a key player in the immune system, SATB1 has been linked to regulating gene expression during the differentiation and activation of T cells. In cancer, SATB1 has been shown to reprogram chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - SATB1 antibody [EPR3951]; All lanes : Anti-SATB1 antibody [EPR3951] at 1/1000 dilution.Lane 1 : Jurkat cell lysates.Lane 2 : Fetal thymus lysates.Lane 3 : Mouse thymus lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 86 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SATB1 antibody [EPR3951]; TA307396, at 1/100 dilution staining SATB1 in paraffin-embedded Human breast carcinoma, by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SATB1 antibody [EPR3951]; TA307396, at 1/100 dilution staining SATB1 in paraffin-embedded Human ovarian adenocarcinoma tissue, by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SATB1 antibody [EPR3951]; TA307396, at 1/100 dilution staining SATB1 in paraffin-embedded Human tonsil tissue, by Immunohistochemistry.

 

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