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Home Antibody All anti-TFF3 antibodies

Anti-TFF3 Antibody EPR3973

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307377 Rabbit monoclonal antibody against TFF3(clone EPR3973) 100ul $325 In Stock
LC418823 TFF3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TFF3 was used as an immunogen.
Clone NameEPR3973 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:500 - 1:1000; ICC: 1:50 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens trefoil factor 3 (intestinal) (TFF3)
Alternative NameITF; P1B; TFI
Database LinkNP_003217
Entrez Gene 7033 Human
FunctionTFF3 belongs to a unique family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with remarkable luminal stability (1). They are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract and have a close association with mucins. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium (2). TFF3 is expressed in goblet cells of the intestines and colon, and has recently been abundantly found in salivary glands (3). TFF3 expression has been detected in neoplastic human colonic mucosa, co-localizing with neutral mucin production, but loss of TFF3 expression is associated with tumor necrosis and advanced Duke's stage (4). Suppression of TFF3 mRNA expression is related to malignant characteristics of thyroid follicular cell-derived tumors and the expression level of TFF3 mRNA is the most promising indicator for diagnosing follicular carcinoma (5). TFF3 is induced in breast carcinomas in a hormone dependent manner (6).
Related PathwaySecreted Protein

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Trefoil Factor 3 antibody [EPR3973]; All lanes : Anti-Trefoil Factor 3 antibody [EPR3973] at 1/1000 dilution.Lane 1 : Human uterus cancer lysate.Lane 2 : Human colon cancer lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 9 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Trefoil Factor 3 antibody [EPR3973]; Immunohistochemical analysis of Trefoil Factor 3 in paraffin-embedded Human colon tissue using TA307377 at 1/500 dilution.
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