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Anti-TFF3 Antibody EPR3973
Also for TFF3 (NM_003226)
|A synthetic peptide corresponding to residues in human TFF3 was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:500 - 1:1000; ICC: 1:50 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens trefoil factor 3 (intestinal) (TFF3)|
|ITF; P1B; TFI|
|TFF3 belongs to a unique family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with remarkable luminal stability (1). They are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract and have a close association with mucins. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium (2). TFF3 is expressed in goblet cells of the intestines and colon, and has recently been abundantly found in salivary glands (3). TFF3 expression has been detected in neoplastic human colonic mucosa, co-localizing with neutral mucin production, but loss of TFF3 expression is associated with tumor necrosis and advanced Duke's stage (4). Suppression of TFF3 mRNA expression is related to malignant characteristics of thyroid follicular cell-derived tumors and the expression level of TFF3 mRNA is the most promising indicator for diagnosing follicular carcinoma (5). TFF3 is induced in breast carcinomas in a hormone dependent manner (6).|
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Western blot - Trefoil Factor 3 antibody [EPR3973]; All lanes : Anti-Trefoil Factor 3 antibody [EPR3973] at 1/1000 dilution.Lane 1 : Human uterus cancer lysate.Lane 2 : Human colon cancer lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 9 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Trefoil Factor 3 antibody [EPR3973]; Immunohistochemical analysis of Trefoil Factor 3 in paraffin-embedded Human colon tissue using TA307377 at 1/500 dilution.