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Home Antibody All anti-TNFRSF4 antibodies

Anti-TNFRSF4 Antibody EPR17Y

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307365
  • Rabbit monoclonal antibody against OX40 (clone EPR17Y )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418746) , 20ug Explanation
100ul 325 In Stock
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WB(1)
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Also for TNFRSF4 (NM_003327)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding extracellular domain of human OX40 was used as an immunogen.
Clone NameEPR17Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500,
Predicted MW Explanation 30 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)
Alternative NameACT35; CD134; IMD16; OX40; TXGP1L
Database LinkNP_003318
Entrez Gene 7293 Human
FunctionTumor necrosis factor receptor superfamily member 4 (OX40, CD134) is a membrane receptor found on activated CD4+ and CD8+ T cells and B cells (1). OX40 binds to OX40 ligand (OX40L) and other TNF receptor-associated factors (TNAF2, TRAF3, TRAF5). OX40-OX40L complex produces CD28 independent co-stimulatory signals. OX40 is involved in the pathologic cytokine storm associated in certain viral infection, such as H4N1 bird flu. OX40 starts a survival signal to the T-cell preventing activation-induced apoptosis, but up regulates cytokine production. Inhibition of OX40 using OX40-immunoglobulin has been linked to reduction of immune overreaction without affecting the viral clearance (2).
Related PathwayTransmembrane Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD134 / OX40 antibody [EPR17Y]; All lanes : Anti-CD134 / OX40 antibody [EPR17Y] at 1/500 dilution.Lane 1 : PMBC cell lysates, untreated.Lane 2 : PMBC cell lysates, treated with TPA.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 30 kDa.Observed band size : 45 kDa .

 

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