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Home Antibody All anti-TNFRSF4 antibodies

Anti-TNFRSF4 Antibody EPR17Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307365
  • Rabbit monoclonal antibody against OX40 (clone EPR17Y )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418746) , 20ug Explanation
100ul 325 In Stock
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WB(1)
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Also for TNFRSF4 (NM_003327)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding extracellular domain of human OX40 was used as an immunogen.
Clone NameEPR17Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500,
Predicted MW Explanation 30 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)
Alternative NameACT35; CD134; IMD16; OX40; TXGP1L
Database LinkNP_003318
Entrez Gene 7293 Human
FunctionTumor necrosis factor receptor superfamily member 4 (OX40, CD134) is a membrane receptor found on activated CD4+ and CD8+ T cells and B cells (1). OX40 binds to OX40 ligand (OX40L) and other TNF receptor-associated factors (TNAF2, TRAF3, TRAF5). OX40-OX40L complex produces CD28 independent co-stimulatory signals. OX40 is involved in the pathologic cytokine storm associated in certain viral infection, such as H4N1 bird flu. OX40 starts a survival signal to the T-cell preventing activation-induced apoptosis, but up regulates cytokine production. Inhibition of OX40 using OX40-immunoglobulin has been linked to reduction of immune overreaction without affecting the viral clearance (2).
Related PathwayTransmembrane Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD134 / OX40 antibody [EPR17Y]; All lanes : Anti-CD134 / OX40 antibody [EPR17Y] at 1/500 dilution.Lane 1 : PMBC cell lysates, untreated.Lane 2 : PMBC cell lysates, treated with TPA.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 30 kDa.Observed band size : 45 kDa .

 

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