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Anti-TNFRSF4 Antibody EPR17Y
Also for TNFRSF4 (NM_003327)
|A synthetic peptide corresponding extracellular domain of human OX40 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)|
|ACT35; CD134; OX40; TXGP1L|
|Tumor necrosis factor receptor superfamily member 4 (OX40, CD134) is a membrane receptor found on activated CD4+ and CD8+ T cells and B cells (1). OX40 binds to OX40 ligand (OX40L) and other TNF receptor-associated factors (TNAF2, TRAF3, TRAF5). OX40-OX40L complex produces CD28 independent co-stimulatory signals. OX40 is involved in the pathologic cytokine storm associated in certain viral infection, such as H4N1 bird flu. OX40 starts a survival signal to the T-cell preventing activation-induced apoptosis, but up regulates cytokine production. Inhibition of OX40 using OX40-immunoglobulin has been linked to reduction of immune overreaction without affecting the viral clearance (2). |
Cytokine-cytokine receptor interaction
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Western blot - CD134 / OX40 antibody [EPR17Y]; All lanes : Anti-CD134 / OX40 antibody [EPR17Y] at 1/500 dilution.Lane 1 : PMBC cell lysates, untreated.Lane 2 : PMBC cell lysates, treated with TPA.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 30 kDa.Observed band size : 45 kDa .