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Anti-FKBP6 Antibody EPR3674
Also for FKBP6 (NM_003602)
|A synthetic peptide corresponding to residues near the C-terminus in human FKBP6 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||FC: 1 : 10 -100, IHC: 1 : 100 -250, WB: 1:1,000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens FK506 binding protein 6, 36kDa (FKBP6), transcript variant 1|
|FK506 binding protein 6 (FKBP6) is a cellular receptor for the immunosuppressants FK506 and rapamycin in the immunophilin FKBP family (1). FKBP’s are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription (2). It forms a complex as FKBP-FK506 to competitively bind to and inhibit the Calcium- and calmodulin-dependent phosphatase calcineurin (3). FKBP6 plays a role in sex-specific fertility as a component of the synaptonemal complex, which is essential for chromosome pairing and meiotic division (4). A genetic deletion in FKBP6 is associated with Williams-Beuren syndrome (WBS), a neurodevelopmental disorder (5).|
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Western blot - FKBP6 antibody [EPR3674]; All lanes : Anti-FKBP6 antibody [EPR3674] at 1/1000 dilution.Lane 1 : Molt-4 cell lysate.Lane 2 : SAOS-2 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit antibody at 1/2000 dilution.Predicted band size : 37 kDa.Observed band size : 38 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FKBP6 antibody [EPR3674]; Ab92475 at 1/100 dilution staining FKBP6 in paraffin-embedded Human tonsil tissue, by immunohistochemistry.