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Anti-IRS2 Antibody EPR1650(2)
Also for IRS2 (NM_003749)
|A synthetic peptide corresponding to residues in human IRS-2 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|pH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens insulin receptor substrate 2 (IRS2)|
Entrez Gene 8660 Human
|Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine (1).|
|Druggable Genome Neurotrophin signaling pathwayInsulin signaling pathwayAdipocytokine signaling pathwayType II diabetes mellitus|
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Western blot - Anti-IRS2 antibody [EPR1650(2)]; All lanes : Anti-IRS2 antibody [EPR1650(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : 293T+insulin cell lysate.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 137 kDa.