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Anti-BCL10 Antibody EPR3174
Also for BCL10 (NM_003921)
|A synthetic peptide corresponding to residues in human Bcl-10 was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; FC: 1:500 - 1:1000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens B-cell CLL/lymphoma 10 (BCL10)|
|c-E10; CARMEN; CIPER; CLAP; mE10|
Entrez Gene 8915 Human
|Bcl-10 is an adaptor protein with a caspase recruitment domain (CARD) that promotes apoptosis and activates pro-caspase 9 and NF-kB (1-2). Bcl-10 also interacts with other CARD domain containing proteins including CARD9, 10, 11 and 14. Bcl-10 is found to form a complex with MALT1, a protein known to be translocated in MALT lymphomas. Bcl-10 and MALT1 play a critical role in antigen receptor-mediated lymphocyte proliferation and signaling to NF-B, which controls the expression of genes critical for cell survival, proliferation, and immune responses (3-4). Defects in Bcl-10 have been identified in various types of cancer.|
|Druggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway|
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Western blot - Bcl10 antibody [EPR3174]; All lanes : Anti-Bcl10 antibody [EPR3174] at 1/1000 dilution.Lane 1 : Daudi cell lysate.Lane 2 : Raji cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 26 kDa.
Flow Cytometry - Bcl10 antibody [EPR3174]; Flow cytometric analysis of Bcl10 in permeabilized Raji cells, using TA307333 at a 1/500 dilution (red) or a Rabbit IgG (negative) (green).