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Anti-AURKB Antibody EPR1010
Also for AURKB (NM_004217)
|A synthetic peptide corresponding to residues in human Aurora-B was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens aurora kinase B (AURKB), transcript variant 1|
|AIK2; AIM-1; AIM1; ARK2; AurB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK12; STK5|
|Aurora-B is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process. Aurora-B is known to be involved in the regulation of centrosome function, bipolar spindle assembly and chromosome segregation. Aurora kinases are localized at the centrosomes of interphase cells, at the poles of the bipolar spindle and in the midbody of the mitotic apparatus. Substrates identified for the Aurora-B kinases include a kinesin-like motor protein, spindle apparatus proteins, histone H3 protein, kinetochore protein and the tumor suppressor protein p53 (1). Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. Identification of Aurora kinases as RasGAP Src homology 3 domain binding protein, also implicates these kinases as potential effectors in the Ras pathway relevant to oncogenesis (2).|
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Western blot - Aurora B antibody [EPR1010]; All lanes : Anti-Aurora B antibody [EPR1010] at 1/1000 dilution.Lane 1 : HeLa treated with nocodazole cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Fetal thymus cell lysate.Lane 4 : A549 cell lysates.Lysates/proteins at 10 µg per lane.Predicted band size : 39 kDa.Observed band size : 39 kDa.