Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens Rho GDP dissociation inhibitor (GDI) alpha (ARHGDIA), transcript variant 2
Synonyms:
GDIA1; RHOGDI; RHOGDI-1
Immunogen
A synthetic peptide corresponding to residues in human Rho-GDI Alpha was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Rho GDI constitutes a family with three mammalian members: Rho-GDI alpha, the ubiquitously expressed archetypal member of the family; Ly/D4-GDI or Rho-GDI beta, which has hematopoietic tissue-specific expression, particularly in B- and T-lymphocytes; and Rho-GDI-3 or -gamma, which is membrane-anchored through an amphipathic helix and is preferentially expressed in the brain, pancreas, lung, kidney and testis (1). RhoGDI’s function by extracting Rho family GTPases including RhoA, Rac1, and Cdc42 from membranes and solubilizing them in the cytosol. Moreover, they interact only with prenylated Rho proteins both in vitro and in vivo. They also inhibit nucleotide exchange and GTP hydrolyzing activities on Rho proteins by interacting with their switch regions and probably restricting accessibility to GEFs and GAPs (2). The N-terminal domain of RhoGDI alpha binds to the switch region of the GTPases, affecting GDP-GTP cycling, whereas the C-terminal domain accommodates the isoprenyl moiety of the GTPases in its hydrophobic pocket, regulating cytosol/membrane partitioning (3). Rho-GDI alpha can be phosphorylated on two sites, serine 101 and serine 174, by PAK (P21-activated kinase) (4).
Related Pathway
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