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Home Antibody All anti-CALD1 antibodies

Anti-CALD1 PHOSPHO Antibody EPR2211Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307306
  • Rabbit monoclonal antibody against Caldesmon Phospho (pT753)(clone EPR2211Y) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for CALD1 (NM_033157)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding threonine 753 of human Caldesmon was used as immunogen.
Clone NameEPR2211Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; ICC: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens caldesmon 1 (CALD1), transcript variant 3
Alternative NameCDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
Database LinkNP_149347
Entrez Gene 800 Human
FunctionCaldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin (1,2). Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and actin-binding region at the C-terminus and a myosin-binding domain at the N-terminus (3). Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin (4). Phosphorylation of non-muscle caldesmon has been linked to reduction of caldesmon's binding properties to actin, myosin, and calmodulin. Also, caldesmon's inhibition of actomyosin ATPase is reduced with its Phosphorylation (5).
Related Pathway Vascular smooth muscle contraction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Caldesmon (phospho T753) antibody [EPR2211Y]; All lanes : Anti-Caldesmon (phospho T753) antibody [EPR2211Y] at 1/1000 dilution.Lane 1 : Hela cell lysate, untreated .Lane 2 : Hela cell lysate, treated with Calyculin A.Lysates/proteins at 10 ug per lane.

 

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