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Anti-CALD1 PHOSPHO Antibody EPR2211Y
Also for CALD1 (NM_033157)
|A synthetic phospho-peptide corresponding to residues surrounding threonine 753 of human Caldesmon was used as immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000; ICC: 1:50 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens caldesmon 1 (CALD1), transcript variant 3|
|CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22|
Entrez Gene 800 Human
|Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin (1,2). Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and actin-binding region at the C-terminus and a myosin-binding domain at the N-terminus (3). Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin (4). Phosphorylation of non-muscle caldesmon has been linked to reduction of caldesmon's binding properties to actin, myosin, and calmodulin. Also, caldesmon's inhibition of actomyosin ATPase is reduced with its Phosphorylation (5).|
| Vascular smooth muscle contraction|
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Western blot - Caldesmon (phospho T753) antibody [EPR2211Y]; All lanes : Anti-Caldesmon (phospho T753) antibody [EPR2211Y] at 1/1000 dilution.Lane 1 : Hela cell lysate, untreated .Lane 2 : Hela cell lysate, treated with Calyculin A.Lysates/proteins at 10 ug per lane.