OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-CALD1 antibodies

Anti-CALD1 PHOSPHO Antibody EPR2211Y

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307306
  • Rabbit monoclonal antibody against Caldesmon Phospho (pT753)(clone EPR2211Y) (Phospho-Specific)
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)
spacer
Also for CALD1 (NM_033157)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding threonine 753 of human Caldesmon was used as immunogen.
Clone NameEPR2211Y IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; ICC: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens caldesmon 1 (CALD1), transcript variant 3
Alternative NameCDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
Database LinkNP_149347
FunctionCaldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin (1,2). Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and actin-binding region at the C-terminus and a myosin-binding domain at the N-terminus (3). Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin (4). Phosphorylation of non-muscle caldesmon has been linked to reduction of caldesmon's binding properties to actin, myosin, and calmodulin. Also, caldesmon's inhibition of actomyosin ATPase is reduced with its Phosphorylation (5).
Related Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Caldesmon (phospho T753) antibody [EPR2211Y]; All lanes : Anti-Caldesmon (phospho T753) antibody [EPR2211Y] at 1/1000 dilution.Lane 1 : Hela cell lysate, untreated .Lane 2 : Hela cell lysate, treated with Calyculin A.Lysates/proteins at 10 µg per lane.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title