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Home Antibody All anti-DFFA antibodies

Anti-DFFA Antibody EPR4222(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307302
  • Rabbit monoclonal antibody against DFF45/DFF35(clone EPR4222(2))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC418008) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for DFFA (NM_004401)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human DFF45/DFF35 was used as an immunogen.
Clone NameEPR4222(2) IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1
Alternative NameDFF-45; DFF1; ICAD
Database LinkNP_004392
FunctionDNA fragmentation factor (DFF) is a heterodimeric protein of 40-kDa (DFF40) and 45-kDa (DFF45) subunits. DFF45 is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFF45 is cleaved by caspase-3. The cleaved fragments of DFF45 dissociate from DFF40, the active component of DFF. DFF40 has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. DFF35 is the short isoform of DFF45.
Related Pathway
Apoptosis

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WB Image
Western blot - ICAD antibody [EPR4222(2)]; All lanes : Anti-ICAD antibody [EPR4222(2)] at 1/10000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : U937 cell lysate.Lane 3 : A431 cell lysate.Lane 4 : A549 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 37 kDa.

 

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