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Home Antibody All anti-DFFA antibodies

Anti-DFFA Antibody EPR4220

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307300
  • Rabbit monoclonal antibody against DFF45 / DFF35(clone EPR4220)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC418008) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for DFFA (NM_004401)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human DFF45/DFF35 was used as an immunogen.
Clone NameEPR4220 IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:500 - 1:1000; ICC: 1:250 - 1:500; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1
Alternative NameDFF-45; DFF1; ICAD
Database LinkNP_004392
FunctionDNA fragmentation factor (DFF) is a heterodimeric protein of 40-kDa (DFF40) and 45-kDa (DFF45) subunits. DFF45 is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFF45 is cleaved by caspase-3. The cleaved fragments of DFF45 dissociate from DFF40, the active component of DFF. DFF40 has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.
Related Pathway
Apoptosis

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - ICAD antibody [EPR4220]; All lanes : Anti-ICAD antibody [EPR4220] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HeLa cell lysate.Lysates/proteins at 10 µg/ml per lane.Predicted band size : 37 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ICAD antibody [EPR4220]; Immunohistochemical staining of paraffin-embedded human breast carcinoma using TA307300 at a diltion of 1/500.
IF Image
Immunocytochemistry/ Immunofluorescence - ICAD antibody [EPR4220]; Immunofluorescent staining of HeLa cells using TA307300 at a dilution of 1/250.

 

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