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Anti-DFFA Antibody EPR4220
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for DFFA (NM_004401)
|A synthetic peptide corresponding to residues in human DFF45/DFF35 was used as an immunogen.|
||FC: 1:10 - 100, ICC: 1:250 - 500, IHC: 1:500 - 1000, IP: 1:10 - 100, WB: 1:1,000-10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1|
|DFF-45; DFF1; ICAD|
|DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kDa (DFF40) and 45-kDa (DFF45) subunits. DFF45 is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFF45 is cleaved by caspase-3. The cleaved fragments of DFF45 dissociate from DFF40, the active component of DFF. DFF40 has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.|
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Western blot analysis on (A) Jurkat and (B) HeLa cell lysates using anti- DFF45/DFF35 RabMAb .
Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-DFF45/DFF35 RabMAb .