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 Home All anti-DFFA antibodies

Anti-DFFA Antibody EPR4220

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA307300
  • Rabbit monoclonal antibody against DFF45 / DFF35(clone EPR4220)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC418008) , 20ug
 100ul $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
Add to Shopping Cart
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
IHC(1)
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Also for DFFA (NM_004401)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human DFF45/DFF35 was used as an immunogen.
Clone NameEPR4220 IsotypeRabbit IgG
Species ReactivityHuman Concentration
Guaranteed Application *WB, IHC Suggested DilutionsFC: 1:10 - 100, ICC: 1:250 - 500, IHC: 1:500 - 1000, IP: 1:10 - 100, WB: 1:1,000-10,000,
BufferStore at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1
Alternative NameDFF-45; DFF1; ICAD
Database LinkNP_004392
FunctionDNA fragmentation factor (DFF) is a heterodimeric protein of 40-kDa (DFF40) and 45-kDa (DFF45) subunits. DFF45 is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFF45 is cleaved by caspase-3. The cleaved fragments of DFF45 dissociate from DFF40, the active component of DFF. DFF40 has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.
Related Pathway
Apoptosis

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis on (A) Jurkat and (B) HeLa cell lysates using anti- DFF45/DFF35 RabMAb .
IHC Image
Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-DFF45/DFF35 RabMAb .

 

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