Transcriptional regulator ERG (ETS-related gene) belongs to a family of transcription factors that shares a highly conserved DNA-binding domain (ETS domain) and differs from each other in other domains (such as absence or presence of the Pointed/SAM domain) (1, 2, 3). ERG has been widely studied in human cancers; TMPRSS2-ERG fusion, which occurs on account of oncogenic translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer (4, 5). ERG is linked to normal processes such as mesoderm formation and is found to form functional complexes with Jun/Fos, with the resulting ternary complexes regulating expression of genes such as metalloprotease-1 (MMP-1) and MMP-3 (1). It may also participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of the local chromatin structure (2). Several isoforms exist, which range from the 35-kDa isoform 7 to the 55-kDa isoform ERG-3 (2).
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