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Anti-EZH2 PHOSPHO Antibody EPR1410


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SKU Description Amount Price Availability*  
TA307294 Rabbit monoclonal antibody against Ezh 2 Phospho (pT487)(clone EPR1410) (Phospho-Specific) 100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding threonine 487 of human Ezh 2 was used as an immunogen. This antibody only detects Ezh 2 phosphorylated at threonine 487.
Clone NameEPR1410 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
Predicted MW Explanation 85 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens enhancer of zeste homolog 2 (Drosophila) (EZH2), transcript variant 2
Alternative NameENX-1; ENX1; EZH1; EZH2b; KMT6; KMT6A; WVS; WVS2
Database LinkNP_694543
Entrez Gene 2146 Human
Entrez Gene 14056 Mouse
Entrez Gene 312299 Rat
FunctionEnhancer of Zeste homolog 2 (Ezh2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone H3. It has been shown that Akt phosphorylates Ezh2 at serine 21 and suppresses its methyltransferase activity by impeding Ezh2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes (1). Ezh2 interacts specifically with Vav both in vitro and in vivo (2). Ezh2 is an essential epigenetic regulator of embryonic development in mice, but its role in the adult organism is unknown. High expression of Ezh2 in developing murine lymphocytes suggests Ezh2 involvement in lymphopoiesis. Data suggest Ezh2-dependent histone H3 methylation as a novel regulatory mechanism controlling Igh rearrangement during early murine B cell development (3).
Related PathwayTranscription FactorsDruggable Genome

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