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Anti-MCM2 PHOSPHO Antibody EPR4121


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against MCM2 Phospho (pS108)(clone EPR4121) (Phospho-Specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 108 of human MCM2 was used as an immunogen. This antibody only detects MCM2 phosphorylated at serine 108.
Clone NameEPR4121 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 102 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens minichromosome maintenance complex component 2 (MCM2), transcript variant 1
Alternative NameBM28; CCNL1; cdc19; CDCL1; D3S3194; MITOTIN
Database LinkNP_004517
Entrez Gene 4171 Human
Entrez Gene 17216 Mouse
Entrez Gene 312538 Rat
FunctionMinichromosome maintenance protein 2 (MCM2) is a member of the MCM family that regulates mammalian DNA replication (1). This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication (2). During cell division, MCM2 is required for the entry into S phase (3). It acts as a factor to license DNA for one and only one round of replication per cell cycle (3). MCM2 physically interacts with and is phosphorylated by Cdc7/Dbf4, thus regulating the initiation of DNA replication (4). Ser27, Ser41, and Ser139 are suggested to be Cdc7/Dbf4 phosphorylation sites in MCM2 (5).
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome DNA replicationCell cycle

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Western blot - MCM2 (phospho S108) antibody [EPR4121]; All lanes : Anti-MCM2 (phospho S108) antibody [EPR4121] at 1/1000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate, treated with Alkaline Phosphatase (AP) .Lysates/proteins at 10 ug per lane.Predicted band size : 102 kDa.
Immunocytochemistry/ Immunofluorescence - MCM2 (phospho S108) antibody [EPR4121]; Immunofluorescent staining of HeLa cells using TA307288 at a dilution of 1/100.


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