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Anti-MCM2 Phospho Antibody EPR4171
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Also for MCM2 (NM_004526)
|A phospho specific peptide corresponding to residues surrounding serine 41 of human MCM2 was used as an immunogen. This antibody only detects MCM2 phosphorylated at serine 41.|
|Human, Mouse, Rat
||ICC: 1:250 - 500, IHC: 1:100 - 250, IP: 1:10 - 100, WB: 1:50,000 - 200,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens minichromosome maintenance complex component 2 (MCM2), transcript variant 1|
|BM28; CCNL1; cdc19; CDCL1; D3S3194; MITOTIN|
|Minichromosome maintenance protein 2 (MCM2) is a member of the MCM family that regulates mammalian DNA replication (1). This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication (2). During cell division, MCM2 is required for the entry into S phase (3). It acts as a factor to license DNA for one and only one round of replication per cell cycle (3). MCM2 physically interacts with and is phosphorylated by Cdc7/Dbf4, thus regulating the initiation of DNA replication (4). Ser27, Ser41, and Ser139 are suggested to be Cdc7/Dbf4 phosphorylation sites in MCM2 (5).|
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Western blot analysis on HeLa cell lysates using anti-Phospho-MCM2 (pS41) RabMAb .
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using Phospho-specific anti-MCM2 (pS41) RabMAb .