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 Home All anti-MCM2 antibodies

Anti-MCM2 Phospho Antibody EPR4171

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SKU Description Amount Price Availability*  
TA307287
  • Rabbit monoclonal antibody against MCM2 Phospho (pS41)(clone EPR4171) (Phospho-Specific)
100ul $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 41 of human MCM2 was used as an immunogen. This antibody only detects MCM2 phosphorylated at serine 41.
Clone NameEPR4171 IsotypeRabbit IgG
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB, IHC Suggested DilutionsICC: 1:250 - 500, IHC: 1:100 - 250, IP: 1:10 - 100, WB: 1:50,000 - 200,000,
BufferStore at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens minichromosome maintenance complex component 2 (MCM2), transcript variant 1
Alternative NameBM28; CCNL1; cdc19; CDCL1; D3S3194; MITOTIN
Database LinkNP_004517
FunctionMinichromosome maintenance protein 2 (MCM2) is a member of the MCM family that regulates mammalian DNA replication (1). This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication (2). During cell division, MCM2 is required for the entry into S phase (3). It acts as a factor to license DNA for one and only one round of replication per cell cycle (3). MCM2 physically interacts with and is phosphorylated by Cdc7/Dbf4, thus regulating the initiation of DNA replication (4). Ser27, Ser41, and Ser139 are suggested to be Cdc7/Dbf4 phosphorylation sites in MCM2 (5).
Related Pathway
Cell cycle

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WB Image
Western blot analysis on HeLa cell lysates using anti-Phospho-MCM2 (pS41) RabMAb .
IHC Image
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using Phospho-specific anti-MCM2 (pS41) RabMAb .

 

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