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Anti-ADIPOQ Antibody EPR3218
Also for ADIPOQ (NM_004797)
|A synthetic peptide corresponding to residues in human Adiponectin was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:50
|pH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), transcript variant 2|
|ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28|
Entrez Gene 9370 Human
|Adiponectin is a multimeric adipocyte-specific secretory protein that regulates energy homeostasis, lipid metabolism, and insulin sensitivity with direct anti-diabetic, anti-atherogenic and anti-inflammatory properties. Adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells and is an important negative regulator in hematopoiesis and immune systems (1, 2). Adiponectin is reported to possibly function as an endogenous factor involved in lipid catabolism and storage or whole body metabolism (3). It is decreased in obesity and has been demonstrated to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules. Adiponectin modulates the inflammatory response of endothelial cells, possibly through cross talk between cAMP-PKA and NF-kappaB signaling pathways (4). |
|Secreted ProteinDruggable Genome PPAR signaling pathwayAdipocytokine signaling pathwayType II diabetes mellitus|
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Western blot - Anti-Adiponectin antibody [EPR3218]; All lanes : Anti-Adiponectin antibody [EPR3218] at 1/1000 dilution.Lane 1 : Human fat lysate.Lane 2 : Human placenta lysate.Lane 3 : Human plasma lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.
Western blot - Anti-Adiponectin antibody [EPR3218]; All lanes : Anti-Adiponectin antibody [EPR3218].Lane 1 : Human plasma lysate treated with Beta-ME and heat.Lane 2 : Human plasma lysate treated with heat only.Lane 3 : Human plasma lysate treated with Beta-ME only.Lane 4 : Human plasma lysate untreated .Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.