Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), transcript variant 2
Synonyms:
ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28
Immunogen
A synthetic peptide corresponding to residues in human Adiponectin was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Adiponectin is a multimeric adipocyte-specific secretory protein that regulates energy homeostasis, lipid metabolism, and insulin sensitivity with direct anti-diabetic, anti-atherogenic and anti-inflammatory properties. Adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells and is an important negative regulator in hematopoiesis and immune systems (1, 2). Adiponectin is reported to possibly function as an endogenous factor involved in lipid catabolism and storage or whole body metabolism (3). It is decreased in obesity and has been demonstrated to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules. Adiponectin modulates the inflammatory response of endothelial cells, possibly through cross talk between cAMP-PKA and NF-kappaB signaling pathways (4).
Related Pathway
Adipogenesis
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B. Western blot analysis on human plasma lysates treated with (A) Beta-ME and heat, (B) heat only, (C) Beta-ME only, and (D) no treatment using anti-Adiponectin RabMAb .
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