Home All anti-ACTN4 antibodies
Anti-ACTN4 Antibody EPR4410
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for ACTN4 (NM_004924)
|A synthetic peptide corresponding to residues in human Alpha-Actinin 4 was used as an immunogen.|
|Human, Mouse, Rat
||IHC: 1:100 - 250, IP: 1:10 - 100, WB: 1:1,000-10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens actinin, alpha 4 (ACTN4)|
|ACTININ-4; FSGS; FSGS1|
|Alpha-actinin is a ubiquitously expressed cytoskeletal protein found in numerous actin structures. It consists of an N-terminal actin-binding domain, a central rod domain, and a C-terminal domain; the protein functions as a homodimer to cross-link actin filaments. The rod domain determines the distance between cross-linked actin filaments and also serves as an interaction site for several cytoskeletal and signaling proteins (1). Alpha-actinin 4 is a non-muscle isoform version of alpha-actinin that is concentrated in the cytoplasm (2). It plays a role in cell motility, invasion, and metastasis of cancer cells (3). Alpha-actinin 4 is commonly expressed in filopodia, lamellipodia, stress fibers, and sites of adhesion (4).|
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Western blot analysis on (A) HeLa, (B) MCF-7, (C) C2C12, (D) A673, and (E) L6 cell lysates using anti-Alpha-Actinin 4 RabMAb .
Immunohistochemical staining of paraffin-embedded human kidney tissue using anti-Alpha-Actinin 4 RabMAb .