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Anti-ACTN4 Antibody EPR4410

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human Alpha-Actinin 4 was used as an immunogen.
Clone Name	EPR4410	Isotype	Rabbit IgG
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	IHC: 1:100 - 250, IP: 1:10 - 100, WB: 1:1,000-10,000,
Buffer	Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens actinin, alpha 4 (ACTN4)
Alternative Name	ACTININ-4; FSGS; FSGS1
Database Link	NP_004915
Function	Alpha-actinin is a ubiquitously expressed cytoskeletal protein found in numerous actin structures. It consists of an N-terminal actin-binding domain, a central rod domain, and a C-terminal domain; the protein functions as a homodimer to cross-link actin filaments. The rod domain determines the distance between cross-linked actin filaments and also serves as an interaction site for several cytoskeletal and signaling proteins (1). Alpha-actinin 4 is a non-muscle isoform version of alpha-actinin that is concentrated in the cytoplasm (2). It plays a role in cell motility, invasion, and metastasis of cancer cells (3). Alpha-actinin 4 is commonly expressed in filopodia, lamellipodia, stress fibers, and sites of adhesion (4).
Related Pathway	Adherens junction Focal Adhesion Hemostasis

Related Lysate from OriGene • Transient overexpression lysate of actinin, alpha 4 (ACTN4) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • ACTN4 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • ACTN4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Actn4 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • ACTN4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Actn4 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens actinin, alpha 4 (ACTN4) as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens actinin, alpha 4 (ACTN4) as transfection-ready DNA • Lenti ORF clone of Human actinin, alpha 4 (ACTN4) , Myc-DDK-tagged • Lenti ORF clone of Human actinin, alpha 4 (ACTN4), mGFP tagged Related cDNA Clones • Homo sapiens actinin, alpha 4 (ACTN4) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)