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Home Antibody All anti-ACTN4 antibodies

Anti-ACTN4 Antibody EPR2533(2)

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SKU Description Amount Price Availability*  
TA307264
  • Rabbit monoclonal antibody against Alpha-Actinin 4(clone EPR2533(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417652) , 20ug Explanation
100ul $325 3 Weeks
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WB(1)
IHC(1)
IF(1)
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Also for ACTN4 (NM_004924)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the N-terminus in human Alpha-Actinin 4 was used as an immunogen.
Clone NameEPR2533(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 105 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens actinin, alpha 4 (ACTN4)
Alternative NameACTININ-4; FSGS; FSGS1
Database LinkNP_004915
Entrez Gene 81 Human
Entrez Gene 60595 Mouse
Entrez Gene 63836 Rat
FunctionAlpha-actinin is a ubiquitously expressed cytoskeletal protein found in numerous actin structures. It consists of an N-terminal actin-binding domain, a central rod domain, and a C-terminal domain; the protein functions as a homodimer to cross-link actin filaments. The rod domain determines the distance between cross-linked actin filaments and also serves as an interaction site for several cytoskeletal and signaling proteins (1). Alpha-actinin 4 is a non-muscle isoform version of alpha-actinin that is concentrated in the cytoplasm (2). It plays a role in cell motility, invasion, and metastasis of cancer cells (3). Alpha-actinin 4 is commonly expressed in filopodia, lamellipodia, stress fibers, and sites of adhesion (4).
Related PathwayDruggable Genome Focal adhesionAdherens junctionTight junctionLeukocyte transendothelial migrationRegulation of actin cytoskeletonSystemic lupus erythematosusMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - alpha Actinin 4 antibody [EPR2533(2)]; All lanes : Anti-alpha Actinin 4 antibody [EPR2533(2)] at 1/1000 dilution.Lane 1 : Fetal skeletal muscle lysate.Lane 2 : A431 cell lysate.Lane 3 : MCF-7 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 105 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - alpha Actinin 4 antibody [EPR2533(2)]; TA307264, at 1/100 dilution, staining alpha Actinin 4 in paraffin-embedded Human kidney tissue by Immunohistochemistry.
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Immunocytochemistry/ Immunofluorescence - alpha Actinin 4 antibody [EPR2533(2)]; TA307264, at 1/100 dilution, staining alpha Actinin 4 in HeLa cells by Immunofluorescence.
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