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Anti-FGB Antibody EPR3082
|A synthetic peptide corresponding to residues in human Fibrinogen beta chain was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||ICC: 1:100, IHC: 1:50 - 100, WB: 1:5,000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens fibrinogen beta chain (FGB), transcript variant 1|
|Fibrinogen is a heterohexamer and contains 2 sets of 3 non-identical chains (alpha, beta, and gamma). Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of soft clot (1). Various cleavage products of fibrinogen and fibrin, released during coagulation and fibrinolysis, repectively, regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types including fibroblasts, endothelial and smooth muscle cells (2). Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogennemia and thrombotic tendency (3,4). An increase in blood fibrinogen concentration has been identified as an independent risk factor for coronary ateroscelerosis and ischemic heart disease (5,6). |
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Western blot - Fibrinopeptide B antibody [EPR3082]; All lanes : Anti-Fibrinopeptide B antibody [EPR3082] at 1/5000 dilution.Lane 1 : Human prostate lysate.Lane 2 : Human plasma lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 56 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Fibrinopeptide B antibody [EPR3082]; ab92510, at a 1/50 dilution, staining Fibrinopeptide B in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry. Detection: by DAB staining