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Anti-FGB Antibody EPR3082


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307249 Rabbit monoclonal antibody against Fibrinogen beta chain (clone EPR3082 ) 100ul $325 In Stock
LC417459 FGB HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Fibrinogen beta chain was used as an immunogen.
Clone NameEPR3082 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsICC: 1:100, IHC: 1:50 - 100, WB: 1:5,000 - 10,000,
Predicted MW Explanation 56 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens fibrinogen beta chain (FGB), transcript variant 1
Alternative NameHEL-S-78p
Database LinkNP_005132
Entrez Gene 2244 Human
FunctionFibrinogen is a heterohexamer and contains 2 sets of 3 non-identical chains (alpha, beta, and gamma). Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of soft clot (1). Various cleavage products of fibrinogen and fibrin, released during coagulation and fibrinolysis, repectively, regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types including fibroblasts, endothelial and smooth muscle cells (2). Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogennemia and thrombotic tendency (3,4). An increase in blood fibrinogen concentration has been identified as an independent risk factor for coronary ateroscelerosis and ischemic heart disease (5,6).
Related PathwaySecreted ProteinDruggable Genome Complement and coagulation cascades

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Fibrinopeptide B antibody [EPR3082]; All lanes : Anti-Fibrinopeptide B antibody [EPR3082] at 1/5000 dilution.Lane 1 : Human prostate lysate.Lane 2 : Human plasma lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 56 kDa.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Fibrinopeptide B antibody [EPR3082]; TA307249, at a 1/50 dilution, staining Fibrinopeptide B in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry. Detection: by DAB staining


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