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Anti-CBL PHOSPHO Antibody EPR2226(2)
|A phospho specific peptide corresponding to residues surrounding Serine 669 of human Cbl was used as an immunogen. This antibody only detects Cbl phosphorylated at Serine 669.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)|
|C-CBL; CBL2; FRA11B; NSLL; RNF55|
|Cbl was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.|
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
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Western blot - CBL (phospho S669) antibody [EPR2226(2)]; All lanes : Anti-CBL (phospho S669) antibody [EPR2226(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysates, untreated .Lane 2 : HeLa cell lysates, treated with pervanadate.Lysates/proteins at 10 µg per lane.Predicted band size : 100 kDa.