ETS transcriptions factors, such as ETS1, regulate numerous proteins and are involved in stem cell development, cell senescence and death, and tumorigenesis (1). Furthermore, it regulates the expression of several angiogenic and extracellular matrix remodeling factors promoting an invasive phenotype (2). The conserved ETS domain within ETS1 is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target proteins (2). ETS-1 is expressed in a variety of cells, including endothelial cells, vascular smooth muscle cells and epithelial cells (2).
TGF Beta Signaling Pathway
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