Homo sapiens Ewing sarcoma breakpoint region 1 (EWSR1), transcript variant 2
Synonyms:
bK984G1.4; EWS
Immunogen
A synthetic peptide corresponding to residues in human EWSR1/EWS was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
EWSR1 / EWS is a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this protein and various proteins that are transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in EWSR1 / EWS are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors (1).
Related Pathway
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