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Anti-HMGB3 Antibody EPR2838
Also for HMGB3 (NM_005342)
|A synthetic peptide corresponding to residues in human Hmgb3 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000
|Preservative: 0.01% Sodium azide|
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens high mobility group box 3 (HMGB3), transcript variant 2|
|HMG-2a; HMG-4; HMG2A; HMG4|
|Hmgb3 belongs to the high mobility group (HMG) protein superfamily. It contains DNA-binding HMG box domains and is thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (1). Hmgb3 is a sequence-independent chromatin-binding protein that is preferentially expressed in hematopoietic stem cells (2). It can alter the DNA structure to facilitate transcription factor binding. Enforced expression of Hmgb3 inhibits B-cell and myeloid differentiation; thus, down-regulation of Hmgb3 protein levels has been concluded to be an important step for myeloid and B-cell differentiation (3). Hmgb3 deficiency possibly leads to a failure of hematopoietic stem cells to expand into normal numbers of common lymphoid and myeloid progenitors. Hmgb3 progenitors attain the ability to expand rapidly and differentiate into normal numbers of hematopoietic cells (4).|
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Western blot - Anti-HMG4 antibody [EPR2838]; All lanes : Anti-HMG4 antibody [EPR2838] at 1/10000 dilution.Lane 1 : Hela cell lysate.Lane 2 : 293T cell lysate.Lane 3 : Human placenta lysate.Lane 4 : JAR cell lysate.Secondary.Goat anti-rabbit HRP conjugated antibody. at 1/2000 dilution.Predicted band size : 23 kDa.