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Anti-HMGB3 Antibody EPR2838


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Hmgb3(clone EPR2838)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Hmgb3 was used as an immunogen.
Clone NameEPR2838 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000
Predicted MW Explanation 23 kDa
BufferPreservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens high mobility group box 3 (HMGB3), transcript variant 2
Alternative NameHMG-2a; HMG-4; HMG2A; HMG4
Database LinkNP_005333
Entrez Gene 3149 Human
Entrez Gene 15354 Mouse
Entrez Gene 305373 Rat
FunctionHmgb3 belongs to the high mobility group (HMG) protein superfamily. It contains DNA-binding HMG box domains and is thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (1). Hmgb3 is a sequence-independent chromatin-binding protein that is preferentially expressed in hematopoietic stem cells (2). It can alter the DNA structure to facilitate transcription factor binding. Enforced expression of Hmgb3 inhibits B-cell and myeloid differentiation; thus, down-regulation of Hmgb3 protein levels has been concluded to be an important step for myeloid and B-cell differentiation (3). Hmgb3 deficiency possibly leads to a failure of hematopoietic stem cells to expand into normal numbers of common lymphoid and myeloid progenitors. Hmgb3 progenitors attain the ability to expand rapidly and differentiate into normal numbers of hematopoietic cells (4).
Related PathwayTranscription Factors

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-HMG4 antibody [EPR2838]; All lanes : Anti-HMG4 antibody [EPR2838] at 1/10000 dilution.Lane 1 : Hela cell lysate.Lane 2 : 293T cell lysate.Lane 3 : Human placenta lysate.Lane 4 : JAR cell lysate.Secondary.Goat anti-rabbit HRP conjugated antibody. at 1/2000 dilution.Predicted band size : 23 kDa.


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