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Home Antibody All anti-MPL antibodies

Anti-MPL Antibody EPR4194

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307223 Rabbit monoclonal antibody against TPOR(clone EPR4194) 100ul $325 In Stock
LC417351 MPL HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
FC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TPOR was used as an immunogen.
Clone NameEPR4194 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:100 - 1:500
Predicted MW Explanation 71 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens MPL proto-oncogene, thrombopoietin receptor (MPL)
Alternative NameC-MPL; CD110; MPLV; THCYT2; TPOR
Database LinkNP_005364
Entrez Gene 4352 Human
Entrez Gene 17480 Mouse
Entrez Gene 366455 Rat
FunctionTPOR is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated (1).
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - TPOR antibody [EPR4194]; All lanes : Anti-TPOR antibody [EPR4194] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : A431 cell lysate.Lane 3 : Human marrow lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 71 kDa.
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Flow Cytometry - Anti-TPOR antibody; Overlay histogram showing MOLT4 cells stained with TA307223 (red line). The secondary antibody used was DyLight 488 goat anti-rabbit IgG (H+L) at 1:500. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1ug/1x10^6 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control.
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