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Home Antibody All anti-ABI1 antibodies

Anti-ABI1 PHOSPHO Antibody EP3954

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307217 Rabbit monoclonal antibody against ABI1 Phospho (pY435)(clone EP3954) (Phospho-Specific) 100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 435 of human ABI1 was used as an immunogen. This antibody only detects ABI1 phosphorylated at tyrosine 435.
Clone NameEP3954 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; ICC: 1:250 - 1:500; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens abl interactor 1 (ABI1), transcript variant 1
Alternative NameABI-1; ABLBP4; E3B1; NAP1BP; SSH3BP; SSH3BP1
Database LinkNP_005461
Entrez Gene 10006 Human
FunctionABI1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, this protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling (1). In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. It regulates ABL1/c-Abl-mediated phosphorylation of MENA, and widely expressed, with highest expression in brain (2).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

 

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