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Anti-ABI1 PHOSPHO Antibody EP3954
Also for ABI1 (NM_005470)
|A phospho specific peptide corresponding to residues surrounding tyrosine 435 of human ABI1 was used as an immunogen. This antibody only detects ABI1 phosphorylated at tyrosine 435.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100; ICC: 1:250 - 1:500; FC: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for IHC-P.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for IHC-P.
|Homo sapiens abl-interactor 1 (ABI1), transcript variant 1|
|ABI-1; ABLBP4; E3B1; NAP1BP; SSH3BP; SSH3BP1|
|ABI1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, this protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling (1). In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. It regulates ABL1/c-Abl-mediated phosphorylation of MENA, and widely expressed, with highest expression in brain (2).|
EGFR1 Signaling Pathway
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Western blot - SSH3BP1 (phospho Y435) antibody [EP3954]; All lanes : Anti-SSH3BP1 (phospho Y435) antibody [EP3954] at 1/10000 dilution.Lane 1 : Jurkat cell lysate, untreated.Lane 2 : Jurkat cell lysate, treated with pervanadate.Lysates/proteins at 10 µg per lane.Predicted band size : 55 kDa.