OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431.
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780.
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210.
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Home All anti-HES1 antibodies
Anti-HES1 Antibody EPR4226
Also for HES1 (NM_005524)
Homo sapiens hairy and enhancer of split 1, (Drosophila) (HES1)
bHLHb39; HES-1; HHL; HRY
A synthetic peptide corresponding to residues in human HES1 was used as an immunogen.
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Human, Mouse, Rat
FC: 1:10 - 100, ICC: 1:100 - 250, IHC: 1:250 - 500, WB: 1:1,000 - 10,000,
HES1 belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box (1).
Delta-Notch Signaling Pathway
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Western blot analysis on (A) fetal brain, (B) PC-12, and (C) SH-SY5Y cell lysates using anti-HES1 RabMAb .
Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-HES1 RabMAb .