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Anti-INPP5D PHOSPHO Antibody EPR425


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against SHIP Phospho (pY1020) (clone EPR425 ) (Phospho-Specific)
100ul 325 In Stock
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Also for INPP5D (NM_005541)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Tyrosine 1020 of human SHIP was used as an immunogen.
Clone NameEPR425 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:20; ICC: 1:250 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2
Alternative Namehp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145
Database LinkNP_005532
Entrez Gene 3635 Human
FunctionSH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2). Phosphorylation on tyrosine 917 and tyrosine 1020 sites in SHIP have been shown to control migration by binding to DOK1, a regulating protein linked to the regulation of migration (3).
Related PathwayDruggable Genome Phosphatidylinositol signaling systemB cell receptor signaling pathwayFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisInsulin signaling pathway

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WB Image
Western blot - SHIP (phospho Y1022) antibody [EPR425]; All lanes : Anti-SHIP (phospho Y1020) antibody [EPR425] at 1/1000 dilution.Lane 1 : Untreated Raji cell lysates .Lane 2 : Raji cell lysates treated with Pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP/AP polymerized antibody.Predicted band size : 133 kDa.Observed band size : 145 kDa .


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