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 Home All anti-INPP5D antibodies

Anti-INPP5D Phospho Antibody EPR425

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA307211
  • Rabbit monoclonal antibody against SHIP Phospho (pY1020) (clone EPR425 ) (Phospho-Specific)
100ul $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
Add to Shopping Cart
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
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Also for INPP5D (NM_005541)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Tyrosine 1020 of human SHIP was used as an immunogen.
Clone NameEPR425 IsotypeRabbit IgG
Species ReactivityHuman Concentration
Guaranteed Application *WB Suggested DilutionsICC: 1:250 - 500, IP: 1:20, WB: 1:1,000 - 10,000,
BufferStore at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2
Alternative Namehp51CN; SHIP; SHIP-1; SHIP1; SIP-145
Database LinkNP_005532
FunctionSH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2). Phosphorylation on tyrosine 917 and tyrosine 1020 sites in SHIP have been shown to control migration by binding to DOK1, a regulating protein linked to the regulation of migration (3).
Related Pathway
Hemostasis

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WB Image
Western blot analysis on Raji cell lysates using anti-Phospho-SHIP (pY1020) RabMAb .

 

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