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Anti-LAMP1 Antibody EPR4204
Also for LAMP1 (NM_005561)
|A synthetic peptide corresponding to residues in human LAMP1 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens lysosomal-associated membrane protein 1 (LAMP1)|
|CD107a; LAMPA; LGP120|
|Lysosome associated membrane glycoprotein 1 (LAMP1) is a type 1 integral membrane protein that is involved in lysosomal exocytosis, movement of lysosomes along microtubules, and fusion of phagosomes with lysosomes (1). The cytoplasmic tail of LAMP1 contains a tyrosine-based motif that mediates sorting in the trans-Golgi network and rapid internalization at the plasma membrane (2). This motif is required for intracellular targeting to lysosomes (2). Furthermore, LAMP1 presents carbohydrate ligands to selectins and is implicated in tumor cell metastasis (3). LAMP1 shares considerable sequence homology with LAMP2, another member of the LAMP family (4). They both have similar domain structures and biochemical properties, since they protect the lysosomal membrane from hydrolytic damage (4). LAMP1 is known to be more abundant than LAMP2, although the loss of LAMP1 causes LAMP2 levels to be elevated (4). The two LAMP proteins are used as membrane markers for intracellular infection (5).|
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Western blot - LAMP1 antibody [EPR4204]; All lanes : Anti-LAMP1 antibody [EPR4204] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : JAR cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : A431 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 45 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - LAMP1 antibody [EPR4204]; Immunohistochemical analysis of LAMP1 in paraffin embedded Human kidney tissue, using ab108597 at a dilution of 1/100.