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Home Antibody All anti-LAMP1 antibodies

Anti-LAMP1 Antibody EPR4204

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307209 Rabbit monoclonal antibody against LAMP1(clone EPR4204) 100ul $325 In Stock
LC417223 LAMP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for LAMP1 (NM_005561)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human LAMP1 was used as an immunogen.
Clone NameEPR4204 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens lysosomal-associated membrane protein 1 (LAMP1)
Alternative NameCD107a; LAMPA; LGP120
Database LinkNP_005552
Entrez Gene 3916 Human
FunctionLysosome associated membrane glycoprotein 1 (LAMP1) is a type 1 integral membrane protein that is involved in lysosomal exocytosis, movement of lysosomes along microtubules, and fusion of phagosomes with lysosomes (1). The cytoplasmic tail of LAMP1 contains a tyrosine-based motif that mediates sorting in the trans-Golgi network and rapid internalization at the plasma membrane (2). This motif is required for intracellular targeting to lysosomes (2). Furthermore, LAMP1 presents carbohydrate ligands to selectins and is implicated in tumor cell metastasis (3). LAMP1 shares considerable sequence homology with LAMP2, another member of the LAMP family (4). They both have similar domain structures and biochemical properties, since they protect the lysosomal membrane from hydrolytic damage (4). LAMP1 is known to be more abundant than LAMP2, although the loss of LAMP1 causes LAMP2 levels to be elevated (4). The two LAMP proteins are used as membrane markers for intracellular infection (5).
Related PathwayES Cell Differentiation/IPSTransmembrane Lysosome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - LAMP1 antibody [EPR4204]; All lanes : Anti-LAMP1 antibody [EPR4204] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : JAR cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : A431 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 45 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - LAMP1 antibody [EPR4204]; Immunohistochemical analysis of LAMP1 in paraffin embedded Human kidney tissue, using TA307209 at a dilution of 1/100.
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