Lysosome associated membrane glycoprotein 1 (LAMP1) is a type 1 integral membrane protein that is involved in lysosomal exocytosis, movement of lysosomes along microtubules, and fusion of phagosomes with lysosomes (1). The cytoplasmic tail of LAMP1 contains a tyrosine-based motif that mediates sorting in the trans-Golgi network and rapid internalization at the plasma membrane (2). This motif is required for intracellular targeting to lysosomes (2). Furthermore, LAMP1 presents carbohydrate ligands to selectins and is implicated in tumor cell metastasis (3). LAMP1 shares considerable sequence homology with LAMP2, another member of the LAMP family (4). They both have similar domain structures and biochemical properties, since they protect the lysosomal membrane from hydrolytic damage (4). LAMP1 is known to be more abundant than LAMP2, although the loss of LAMP1 causes LAMP2 levels to be elevated (4). The two LAMP proteins are used as membrane markers for intracellular infection (5).
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