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Home Antibody All anti-RBBP4 antibodies

Anti-RBBP4 Antibody EPR3411

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307203
  • Rabbit monoclonal antibody against RBBP4 (clone EPR3411 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417190) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for RBBP4 (NM_005610)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the N-term of human RBBP4 was used as an immunogen.
Clone NameEPR3411 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF: 1:100 - 1:250; WB: 1:10000 - 1:50000; IP: 1:50; IHC-P: 1:100 - 1:250; FC: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens retinoblastoma binding protein 4 (RBBP4), transcript variant 1
Alternative Namelin-53; NURF55; RBAP48
Database LinkNP_005601
FunctionRBBP4 is a core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. RBBP4 is a component of several complexes which regulate chromatin metabolism. These complexes include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair as well as the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (1) The growth suppression function of the retinoblastoma protein (Rb) is thought to be mediated by Rb binding to cellular proteins. Rb interacts with multiple cellular proteins that mediate its cellular function. p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein (2). Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb. RbAp48 (RBBP4) and RbAp46 are quantitatively the major Rb-associated proteins. Results suggest that RBBP4 and RbAp46 may have shared as well as unique functions in the regulation of cell proliferation and differentiation (3).
Related Pathway

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WB Image
Western blot - RbAp48 antibody [EPR3411]; All lanes : Anti-RbAp48 antibody [EPR3411] at 1/50000 dilution.Lane 1 : HeLa lysate.Lane 2 : Jurkat lysate.Lane 3 : NIIH/3T3 lysate.Lane 4 : 293 lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 48 kDa.Observed band size : 48 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RbAp48 antibody [EPR3411]; TA307203, at 1/100 dilution, staining RbAp48 in human breast carcinoma tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - RbAp48 antibody [EPR3411]; Immunofluorescent staining of RbAp48 in HeLa cells using TA307203 at 1/100 dilution.

 

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