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Anti-RHEB Antibody EPR2971
Also for RHEB (NM_005614)
|A synthetic peptide corresponding to residues in human Rheb was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||FC: 1:100, ICC: 1:100 - 250, IHC: 1:100 - 250, WB: 1:2000 - 5000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens Ras homolog enriched in brain (RHEB)|
Entrez Gene 6009 Human
|Rheb (Ras Homolog Enriched in brain) is a Ras-like small guanosine triphosphatase (GTPase) that is involved in cell growth and cell cycle progression. Rheb has also been suggested to have involvement in the TOR/S6K signaling pathway (1). It regulates the activity of the mammalian target of rapamycin, mTOR, a central regulator of cell growth, in response to growth factor stimulation and nutrient availability (2). It also interacts with and appears to regulate Raf-1 kinase, an essential component of the H-Ras signaling pathway, and is suggested to function in concert with H-Ras to dynamically integrate cAMP and growth factor signaling (3). |
| mTOR signaling pathwayInsulin signaling pathway|
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Western blot - RHEB antibody [EPR2971]; All lanes : Anti-RHEB antibody [EPR2971] at 1/2000 dilution.Lane 1 : Raji cell lsyate.Lane 2 : SH-SY5Y cell lsyate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 20 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RHEB antibody [EPR2971]; TA307202, at 1/100 dilution, staining RHEB in paraffin-embedded Human brain tissue, by Immunohistochemistry.