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Anti-TMPRSS2 Antibody EPR3862
Also for TMPRSS2 (NM_005656)
|A synthetic peptide corresponding to residues on the C-terminus in the extracellular domain in human TMPRSS2 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:500 - 1:1000; ICC: 1:500 - 1:1000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens transmembrane protease, serine 2 (TMPRSS2), transcript variant 2|
Entrez Gene 7113 Human
Entrez Gene 50528 Mouse
Entrez Gene 156435 Rat
|Transmembrane protease, serine 2 (TMPRSS2) is a type-II transmembrane serine protease. It encodes a type II trans-membrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. The biological function of TMPRSS2 is unknown; however, seine proteases are known to be involved in many physiological and pathological processes (1). TMPRSS2 is expressed highly in primary and metastatic prostate cancers. It is also regulated by androgens and is associated with tumor cell differentiation (1, 2), making it a potential target for cancer therapy and diagnosis. TMPRSS2-ERG fusion, which occurs on account of translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer (3, 4).|
|Secreted ProteinTransmembraneProteaseDruggable Genome |
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Western blot - TMPRSS2 antibody [EPR3862]; All lanes : Anti-TMPRSS2 antibody [EPR3862] at 1/1000 dilution.Lane 1 : Human prostate tissue lysate .Lane 2 : Human prostate tissue lysate .Lysates/proteins at 10 ug per lane.Predicted band size : 54 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TMPRSS2 antibody [EPR3862]; Immunohistochemical analysis of paraffin-embedded Human prostatic adenocarcinoma using TA307199 at a dilution of 1/500.