Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for Rac-dependent cytoskeletal reorganization in response to growth factor stimulation (1). Abi-2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases Abi-1 and/or Abi-2. This protein may be involved in cytoskeletal reorganization, and it regulates Abi-1/c-Abl-mediated phosphorylation of MENA (2).
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