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Home Antibody All anti-BCAS2 antibodies

Anti-BCAS2 Antibody EPR4376

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307187
  • Rabbit monoclonal antibody against BCAS2(clone EPR4376)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417014) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for BCAS2 (NM_005872)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human BCAS2 was used as an immunogen.
Clone NameEPR4376 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens breast carcinoma amplified sequence 2 (BCAS2)
Alternative NameDAM1; Snt309; SPF27
Database LinkNP_005863
FunctionBCAS2 (Breast carcinoma-amplified sequence 2), also known as pre-mRNA-splicing factor SPF27, is a ubiquitously expressed protein that was initially identified as overexpressed and amplified in breast cancer cell lines (1). It is a component of the spliceosome and is involved in mRNA splicing (1, 2). BCAS2 interacts with estrogen receptor (ER) beta, TR beta, PR, and PPAR gamma in a ligand-independent way (1). BCAS2 has been reported to be a transcriptional coactivator of estrogen receptor and a novel negative regulator of p53 (3). Thus, BCAS2 might play an important role in breast cancer development and potentially become a molecular target for cancer therapy (1).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-BCAS2 antibody [EPR4376]; All lanes : Anti-BCAS2 antibody [EPR4376] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate .Lane 2 : MCF-7 cell lysate .Lane 3 : SKBR-3 cell lysate .Lane 4 : C6 cell lysate .Lane 5 : PC-12 cell lysate .Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.

 

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