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Anti-MAPT PHOSPHO Antibody EPR2731
Also for MAPT (NM_016841)
|A phospho specific peptide corresponding to residues surrounding serine 396 of human Tau was used as an immunogen. This antibody only detects Tau phosphorylated at serine 396.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 4|
|DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU|
|Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Tau's association with the membrane cortex during AD progression, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).|
MAPK signaling pathway
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Western blot - Tau (phospho S396) antibody [EPR2731]; All lanes : Anti-Tau (phospho S396) antibody [EPR2731] at 1/10000 dilution.Lane 1 : SH-SY5Y cell lysates, untreated.Lane 2 : SH-SY5Y cell lysates, treated with Alkaline Phosphatase.Lysates/proteins at 10 µg per lane.Predicted band size : 79 kDa.