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Anti-MAPT PHOSPHO Antibody EPR2605
Also for MAPT (NM_016841)
|A phospho-specific peptide corresponding to residues surrounding Serine 404 of human Tau was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||IHC: 1:100 - 250, WB: 1:1,000 - 2,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 4|
|DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU|
|Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).|
MAPK signaling pathway
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Western blot - Tau (phospho S404) antibody [EPR2605]; All lanes : Anti-Tau (phospho S404) antibody [EPR2605] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate (Untreated).Lane 2 : SH-SY5Y cell lysate (Treated with Okadaic Acid and Calyculin A).Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 79 kDa.