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Home Antibody All anti-MAPT antibodies

Anti-MAPT PHOSPHO Antibody EPR2400

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307178
  • Rabbit monoclonal antibody against Tau Phospho (pS198) (clone EPR2400 ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for MAPT (NM_016841)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding serine 198 of human Tau was used as an immunogen. The antibody only detects Tau phosphorylated on serine 198.
Clone NameEPR2400 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50000 - 1:100000; IP: 1:50; IHC-P: 1:100 - 1:250; ICC: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens microtubule-associated protein tau (MAPT), transcript variant 4
Alternative NameDDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
Database LinkNP_058525
FunctionTau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Serine 199/202, Threonine 231, and Serine 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Serine 396 (4).
Related Pathway
MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Tau (phospho S198) antibody [EPR2400]; All lanes : Anti-Tau (phospho S198) antibody [EPR2400] at 1/100000 dilution.Lane 1 : SH-SY5Y cell lysate.Lane 2 : SH-SY5Y cell lysate treated with AP.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 79 kDa.Observed band size : 50 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho S198) antibody [EPR2400]; TA307178, at 1/100 dilution, staining Tau (phospho S198) in paraffin-embedded human brain tissue by Immunohistochemistry.

 

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